目次

• Linking microbial genetic resources in culture collections with nucleic acid sequences
• Three levels of “Linking” are:
• PPT Slide
• Three methods for “Linking”
• (1) by central indexing
• EX1: CCINFO, STRAINS and other databases in WDCM
• PPT Slide
• EX2: Genome Information Broker of DDBJ
• Comparative genomics in GIB
• Data explosion and frequent update EX) 9.17 Gbp in 7.57M entries
• (2) by a parallel processing of a query
• PPT Slide
• (3) based on interoperability
• Our motive of “Linking” is:
• Comparative genomics
• PPT Slide
• COG* (Clusters of Orthologous Groups of proteins) - tree by the information theory (* Koonin E. V. et al (1998))
• DNA Chip data
• Clustering of DNA Chip data
• Aiming at the L3 link, we started developing a workbench (WB) three years ago and the current status is:
• The WB can import XML files
• The WB can integrate CORBA databases and analytical tools
• You can evaluate the consistency between results of NT and phylogenetic analysis in the WB
• In the meantime, it becomes obvious for us that the 3rd level “Linking” requires not only such information technologies as XML and CORBA but also:
• PPT Slide
• Ultimate “Linking” of cultures and genomic information is:
• Linking of living cell in vitro and in silico
• Acknowledgements