研究活動 : 私たちの研究室では主に以下のような研究をおこなっています。
  • EST配列決定とDNAチップを用いたプラナリア脳での遺伝子発現様式
  • 多細胞生物における遺伝子発現様式の比較解析による進化の研究
  • 形態形成を支配するホメオボックス遺伝子の分子進化
  • ヒトゲノム遺伝子構成の進化
  • バクテリアゲノム間での遺伝子の水平移動の検出と遺伝子構成の進化
  • 神経伝達物質受容体遺伝子の分子進化
  • 魚類における性染色体の進化
  • ウイルスの分子進化
  • 遺伝子発現から見た眼の構造の進化
  • 自然選択検出法の開発
主な論文 : 主要論文リスト(1981-2007)

The Rice Annotation Project: Ito, T. and Gojobori, T., et al. (2007).
Curated Genome Annotation of Oryza sativa ssp. Japonica and Comparative Genome Analysis with Arabidopsis thaliana. Genome Research 17, 175-183.

The FANTOM Consortium: Carninci, P., Gojobori, T., and other 158 authors
and Hume, D.A. and Riken Genome Exploration Research Group and Genome Science Group.
(Genome Network Project Core Group):Kai, C., and other 31 authors and Hayashizaki, Y. (2005)
The Transcriptional Landscape of the Mammalian Genome. Science 309(5740), 1559-1563.

(International Rice Genome Sequencing Project: Annotation and Analysis)
Iwama, H., Gojobori, T., Itoh, T., Niimura, Y., Fujii, Y.,Habara, T., Sakai. H., Sato, Y., Wilson, G.,Kumar, K., McCouch, S., Juretic, N., Hoen, D., Wright, S., Bruskiewich, R.,  Bureau, T., Miyao, A., Hirochika, H., Nishikawa,T., Kadowaki, K. and Sugiura, M. (2005) The map-based sequence of the rice genome.
Nature436, 793-800.

Tateno, Y., Saitou, N., Okubo, K., Sugawara, H. and Gojobori, T. (2005).
DDBJ in collaboration with mass-sequencing teams on annotation. Nucleic Acids Res.33, D25-D28.

Nakamura, Y., Itoh, T., Matsuda, H. and Gojobori, T. (2004). Biased biological functions of horizontally transferred genes on 324,653 open reading frames of 116 prokaryotic complete genomes.
Nature Genetics 36(7): 760-766

Iwama, H. and Gojobori, T. (2004).
Highly conserved upstream sequences for transcription factor genes and implications for the regulatory network.
Proc. Natl. Acad. Sci. USA. 101, 17156-61.

Imanishi, T., other 152 authors, Gojobori, T.*, and Sugano S. (2004). Integrative annotation of 21,037 human genes validated by full-length cDNA clones. (*correspondence author) PLoS Biol. 2, 1-21.

Andrews, T. D. and Gojobori, T. (2004).
Strong positive selection and recombination drive
the antigenic variation of the PilE protein of the human pathogen neisseria meningitidis.Genetics 166, 25-32.

Anzai, T., Shiina, T., Kimura, N., Yanagiya, K., Kohara, S., Shigenari, A., Yamagata, T., Kulski, J. K., Naruse, T. K., Fujimori, Y., Fukuzumi, Y., Yamazaki, M., Tashiro, H., Iwamoto, C., Umehara, Y., Imanishi, T., Meyer, A., Ikeo, K., Gojobori, T., Bahram, S. and Inoko, H. (2003). Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence. Proc Natl Acad Sci USA. 100(13):7708-13

Nakazawa, M., Cebria, F., Mineta, K., Ikeo, K., Agata, K. and Gojobori, T. (2003).
Search for the evolutionary origin of a brain. ; Planarian brain characterized by microarray.
Mol Biol Evol. 20(5): 784-91

Mineta, K., Nakazawa, M., Cebria, F., Ikeo, K., Agata, K. and Gojobori, T. (2003). Origin and evolutionary process of CNS elucidated by comparative genomics analysis of planarian ESTs.
Proc Natl Acad Sci USA. 100(13): 7666-671

Nishio, Y., Nakamura, Y., Kawarabayashi, Y., Usuda, Y., Kimura, E., Sugimoto, S., Matsui, K., Yamagishi, A., Kikuchi, H., Ikeo, K. and Gojobori, T. (2003). Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens.
Genome Res. 13(7): 1572-79

Niimura, Y. and Gojobori, T. (2002)
In silico chromosome staining: Reconstruction of Giemsa bands from the whole human genome sequence. Proc Natl Acad Sci USA. 99(2): 797-802

Tanaka, Y., Hanada, K., Mizokami, M., Yeo, A. E. T.,
Shih, J. W.-K., Gojobori, T.. and Alter, H. J. (2002).
A Comparison of the molecular clock of hepatitis c virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades. Proc Natl Acad Sci USA. 99, 15584-89.

Sasaki, T., Yamamoto, K., Sakata, K., Baba, T., Katayose, Y., Wu, J., Niimura Y., Cheng Z., Nagamura Y., Kanamori, H., Hosokawa, S., Masukawa, M., Arikawa, Antonio, B.A., .., and Gojobori, T. (2002) The genome sequence and structure of rice chromosome 1. Nature 420, 312-316

Cebria, F., Kobayashi, C., Umesono, Y., Nakazawa, M., Mineta, K., Ikeo, K., Gojobori, T.., Itoh, M., Taira, M., Alvarado, A. and Agata, K. (2002).
FGFR-related gene nou-darake restricts brain tissues to the head region of planarians. Nature 419, 620-24.

Fantom Consortium (Okazaki, Y., Gojobori, T., et al.), Riken Genome Exploration Research Group Phase I & II Team, Mouse Genome Sequencing Consortium, Scientific management: Y. Hayashizaki (2002) Analysis of the Mouse Transcriptome based on Functional Annotation of 60,770 full-length cDNAs. Nature 420: 563-573

Akashi, H. and Gojobori, T. (2002)
Metabolic efficiency and amino acid composition in the proteomes of Escherichia coli and Bacillus subtilis. Proc Natl Acad Sci USA. 99(6):3695-3700

RIKEN Genome Exploration Research Group Phase II Team and FANTOM Consortium (Okazaki, Y., Gojobori, T., et al.), Genelal organizer: Y.Hayashizaki (2001) Functional anotation of a full-length mouse cDNA collection. Nature 409(6821): 685-690.

International Human Genome sequencing Consortium (DNA sequence databases: DNA Data Bank of Japan et.al ) (2001)
Initial sequencing and analysis of the human genome. Nature 409(6822): 860-921.

Gaudieri, S., Dawkins, R.L., Habara, K., Kulski, J.K.,
and Gojobori, T. (2000) SNP profile within the human major histocompatibility complex reveals an extreme and interrupted level of nucleotide diversity. Genome Res.10(10): 1579-1586

Yamaguchi-Kabata, Y. and Gojobori, T. (2000)
Reevaluation of amino acid variability of the human
immunodeficiency virus type 1 gp120 envelope glycoprotein and prediction of new discontinuous epitopes. J.Virology 74(9):4335-4350

Suzuki, Y. and Gojobori, T. (1999)
A method for detecting positive selection at single amino acid sites. Mol Bol Evol. (16): 1315-1328.

Gaudieri, S., Kulski, J., Dawkins, R., and Gojobori, T. (1999) Different evolutionary histories in two subgenomic regions of the major histocompatibility complex. Genome Res. 9(6): 541-549.

Bellgard, M. and Gojobori, T. (1999)
Inferring the direction of evolutionary changes of
genomic base composition.Trends in Genetics 15(7): 254-256.

Itoh, T., Takemoto, K., Mori, H., and Gojobori, T. (1999) Evolutionary instability of operon structures disclosed by sequence comparisons of complete microbial genomes.
Mol Biol Evol. 16(3): 332-346.

Watanabe, H., Mori, H., Itoh, T., and Gojobori, T. (1997) Genome plasticity as a paradigm of eubacteria evolution. J Mol Evol. 44(Suppl 1): S57-S64.

Yamaguchi, Y. and Gojobori, T. (1997)
Evolutionary mechanisms and population dynamics of the third variable envelope region of HIV within single hosts. Proc Natl Acad Sci USA. 94(4): 1264-1269.

Gojobori, T., Tateno, Y., and Ohta, T., ed. (1997)
Special Issue: Networks and Evolution of Molecular Information. J Mol Evol., ed.^eds. Vol. 44. S1-S180.

Fumihito, A., Miyake, T., Takada, M., Shingu, R., Endo, T. Gojobori, T., Kondo, N., and Ohno, S. (1996) Monophyletic origin and unique dispersal patterns of domestic fowls. Proc Natl Acad Sci. USA. 93(13): 6792-6795.

Endo, T., Ikeo, K., and Gojobori, T. (1996)
Large-scale search for genes on which positive selection may operate.
Mol Biol Evol. 13(5): 685-690.

Miura, T., Fukunaga, T., Igarashi, T., Yamashita, M. Ido, E., Funahashi, S.-i., Ishida, T., Washio, K., Ueda, S. Hashimoto, K.-i., Yoshida, M., Osame, M., Singhal, B.S., Zaninovic, V. Cartier, L., Sonoda, S., Tajima, K., Ina, Y., Gojobori, T., and Hayami, M. (1994) Phylogenetic subtypes of human T-lymphotropic virus type I and their relations to the anthropological background. Proc Natl Acad Sci USA. 91: 1124-1127.

Gojobori, T. and Ikeo, K. (1994)
Molecular evolution of serine protease and its inhibitor with special reference to domain evolution.  Philos Trans R Soc Lond B Biol Sci. 344(1310): 411-415.

Ishibashi, K., Sasaki, S., Fushimi, K., Uchida, S., Kuwahara, M. Saito, H., Furukawa, T., Nakajima, K., Yamaguchi, Y., Gojobori, T., and Marumo, F. (1994) Molecular cloning and expression of a member of the aquaporin family with permeability to glycerol and urea in addition to water expressed at the basolateral membrane of kidney collecting duct cells. Proc Natl Acad Sci USA. 91(14): 6269-6273

Ina, Y. and Gojobori, T. (1994)
Statistical analysis of nucleotide sequences of the hemagglutinin gene of human influenza A viruses. Proc Natl Acad Sci USA. 91(18): 8388-8392.

Gojobori, T., Imanishi, T., Ina, Y., Saitou, N., Tateno, Y. Sato, K., Takata, H., Kimura, A., Nishimura, Y., Akaza, T. Miyoshi, H., Mura, T., Tokunaga, K., Tanaka, H., Konoeda, Y. Wakisaka, A., Juji, T., Sasazuki, T., Tsuji, K., and Inoko, H. (1992) Construction of the MHC database. in HLA 1991, Proceedings of the Eleventh International Histocompatibility Workshop and Conference.
Oxford University Press, Oxford.

Gojobori, T., Moriyama, E.N., and Kimura, M. (1990)
Statistical methods for estimating sequence divergence. Methods Enzymol. 183: 531-550.

Gojobori, T., Moriyama, E., and Kimura, M. (1990)
Molecular clock of viral evolution, and the neutral theory. Proc Natl Acad Sci USA. 87(24): 10015-10018.

Gojobori, T., Moriyama, E.N., Ina, Y., Ikeo, K.
Miura, T., Tsujimoto, H., Hayami, M., and Yokoyama, S. (1990)
Evolutionary origin of human and simian immunodeficiency viruses. Proc Natl Acad Sci USA. 87(11): 4108-4111.

Orito, E., Mizokami, M., Ina, Y., Moriyama, E.N., Kameshima, N. Yamamoto, M., and Gojobori, T. (1989) Host-independent evolution and a genetic classification of the hepadnavirus family based on nucleotide sequences. Proc Natl Acad Sci USA. 86(18): 7059-7062.

Tsujimoto, H., Hasegawa, A., Maki, N., Fukasawa, M., Miura, T. Speidel, S., Cooper, R.W., Moriyama, E.N., Gojobori, T., and Hayami, M. (1989) Sequence of a novel simian immunodeficiency virus from a wild-caught African mandrill. Nature 341(6242): 539-541.

Nei, M. and Gojobori, T. (1986)
Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. Mol Biol Evol. 3(5): 418-426.

Gojobori, T. and Yokoyama, S. (1985)
Rates of evolution of the retroviral oncogene of Moloney murine sarcoma virus and of its cellular homologues. Proc Natl Acad Sci USA. 82(12): 4198-4201.

Shimotohno, K., Takahashi, Y., Shimizu, N., Gojobori, T. Golde, D.W., Chen, I.S.Y., Miwa, M., and Sugimura, T. (1985) Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: An open reading frame for the protease gene. Proc Natl Acad Sci USA. 82(10): 3101-3105.

Gojobori, T. (1983) Codon substitution in evolution and the "saturation" of synonymous changes. Genetics 105(4): 1011-1027.

Li, W.-H., Gojobori, T., and Nei, M. (1982)
Reply on Goodman's comment "Positive selection causes purifying selection". Nature 295: 630.

Gojobori, T., Li, W.-H., and Graur, D. (1982)
Patterns of nucleotide substitution in pseudogenes and functional genes. J Mol Evol. 18(5): 360-369.

Gojobori, T., Ishii, K., and Nei, M. (1982)
Estimation of average number of nucleotide substitutions when the rate of substitution varies with nucleotide. J Mol Evol. 18(6): 414-423.

Li, W.-H., Gojobori, T., and Nei, M. (1981)
Pseudogenes as a paradigm of neutral evolution.
Nature 292(5820): 237-239.

過去の発表論文 : PubMedからご紹介します(ここをクリック!)。

過去の研究活動 : 研究内容・業績(1995年遺伝研年報より)
研究内容・業績(1996年遺伝研年報より)
研究内容・業績(1997年遺伝研年報より)
研究内容・業績(1998年遺伝研年報より)
研究内容・業績(1999年遺伝研年報より)
研究内容・業績(2000年遺伝研年報より)
研究内容・業績(2001年遺伝研年報より)
研究内容・業績(2002年遺伝研年報より)
研究内容・業績(2003年遺伝研年報より)
研究内容・業績(2004年遺伝研年報より)
研究内容・業績(2005年遺伝研年報より)


Copyright(c) 2004 H Ohyanagi, AO, YK, KO, TU and TG